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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Sucrose gap ： ウィキペディア英語版 Sucrose gap The sucrose gap technique is used to create a conduction block in nerve or muscle fibers. A high concentration of sucrose is applied to the extracellular space to increase resistance between two groups of cells, which prevents the correct opening and closing of sodium and potassium channels. It was originally developed by Robert Stämpfli for recording action potentials in nerve fibers, and is particularly useful for measuring irreversible or highly variable pharmacological modifications of channel properties since untreated regions of membrane can be pulled into the node between the sucrose regions. ==History== The sucrose gap technique was first introduced by Robert Stämpfli in 1954 who worked with Alan Hodgkin and Andrew Huxley between 1947 and 1949. From his research, Stämpfli determined that currents moving along nerve fibers can be measured more easily when there is a gap of high resistance that reduces the amount of conducting medium outside of the cell. Stämpfli observed many problems with the ways that were being used to measure membrane potential at the time. He experimented with a new method that he called the sucrose gap. The method was used to study action potentials in nerve fibers.〔 Huxley observed Stämpfli’s method and agreed that it was useful and produced very few errors. The sucrose gap technique also contributed to Stämpfli's and Huxley's discovery of inhibitory junction potentials. Since its introduction, many improvements and alterations have been made to the technique. One modification of the single sucrose gap method was introduced by C.H.V. Hoyle in 1987. The double sucrose gap technique, which was first used by Rougier, Vassort, and Stämpfli to study cardiac cells in 1968, was improved by C. Leoty and J. Alix who introduced an improved chamber for the double sucrose gap with voltage clamp technique which eliminated external resistance from the node. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Sucrose gap」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.